Tag: M.W:100-200

20197-75-5, Methyl 1,4-Benzodioxan-6-carboxylate is a benzodioxans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,20197-75-5

(3) step (2) the obtained solid product, ethanol, reflux reaction of hydrazine hydrate, the obtained solid product;Step (2) the obtained solid product, ethanol, the proportion of the amount of the hydrazine hydrate is 0.1: 2 : 0.5, wherein step (2) in the obtained solid product of mmol, ethanol, hydrazine hydrate to meter ml, reflux the reaction time is 15h.

The synthetic route of 20197-75-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Shandong University of Technology; Shu, Juan; Lian, Zhimin; Zhu, Hailiang; Xu, Yizeng; Sun, Liqin; gao, Leilei; (12 pag.)CN105777731; (2016); A;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20197-75-5,Methyl 1,4-Benzodioxan-6-carboxylate,as a common compound, the synthetic route is as follows.

(2) Synthesis of Compound 1 (0146) The compound k (2.01 g), NBS (8.48 g), and carbon tetrachloride (125 ml) were introduced to an eggplant-shaped flask. Then, AIBN (340 mg) was added thereto in a nitrogen atmosphere and heated to reflux for 44 hours. The reaction solution was extracted with chloroform. Subsequently, the extract was washed with saturated saline, dehydrated with sodium sulfate, and concentrated. The concentrate was purified by silica gel column chromatography (Wakosil? C-300) using chloroform alone as an eluent. Thus, the compound 1 was obtained (yield: 2.64 g; yield rate: 73percent).

20197-75-5, As the paragraph descriping shows that 20197-75-5 is playing an increasingly important role.

Reference£º
Patent; RIKEN; Nakano, Takeshi; ASAMI, Tadao; OSADA, Hiroyuki; (31 pag.)US2017/305886; (2017); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

31127-39-6, 2,3-Dihydrobenzo[b][1,4]dioxine-6-carbaldehyde oxime is a benzodioxans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,31127-39-6

General procedure: To a solution of 2,3-dihydrobenzo[b][1,4]dioxine-6-carbaldehyde oximes 10 (2.69 g, 15.0 mmol) in THF (70 mL) at room temperature under nitrogen atmosphere, N-chlorosuccinimide (2.40 g, 18.0 mmol) and pyridine (120 muL, 1.50 mmol) were added. After being stirred for 40 min at 60 C, the mixture was cooled to rt and solutions of propargyl alcohol (700 muL, 12.0 mmol) in THF (2 mL) and triethylamine (2.50 mL, 18.0 mmol) in THF (4 mL) were added dropwise successively. After the mixture being stirred at 50 C for 2 h. Saturated NaHCO3 solution was added and the mixture was extracted with ethyl acetate (50 mL ¡Á 3). The organic layers were dried over anhydrous MgSO4 and concentrated. The residue was purified by flash column chromatography (hexane:EtOAc =2:1) to give the isoxazole alcohol 11 (when R2= 2,3-dihydrobenzo[b][1,4]dioxin-6-yl, 1.87 g, 67%). To a solution of thus prepared alcohol 11 (1.16 g, 5.00mmol) in dichloromethane (15 mL) at room temperature, pyridinium chlorochromate (2.16 g, 10.0 mmol) and 4 A molecular sieve (4.00 g) were added. After being stirred for 4 h, the mixture was concentrated and the residue was purified by flash column chromatography (hexane:EtOAc =3:1) to give the building block 3 (when R2= 2,3-dihydrobenzo[b][1,4]dioxin-6-yl, 740 mg, 65%). 1H NMR (500 MHz, CDCl3) delta 9.95 (s, 1H), 7.31 (s, 1H), 7.27 (d, J = 8.0 Hz, 1H), 7.13 (s, 1H), 6.90 (d, J = 8.0 Hz,1H), 4.22-4.27 (m, 4H). Other isoxazole aldehyde derivatives were synthesizedanalogously and identified with the 1H NMR spectroscopy.

As the paragraph descriping shows that 31127-39-6 is playing an increasingly important role.

Reference£º
Article; Oh, Yoo Na; Kwak, Jumyung; Koh, Hun Yeong; Jung, Sun Ho; Bulletin of the Korean Chemical Society; vol. 33; 12; (2012); p. 4227 – 4230;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

A common heterocyclic compound, the benzodioxans compound, name is 2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid,cas is 3663-80-7, mainly used in chemical industry, its synthesis route is as follows.

Example 12,3-dihydro-1,4-benzodioxine-2-carboxylic acid (0.38 mol; 68.51 g) and tetrahydrofuran (500 ml) were charged and contents were stirred at 20-25¡ã C. for 5-10 min to get a clear solution. N,N-carbonyl diimidazole (0.407 mol; 66.28 g) along with tetrahydrofuran (500 ml) was added to the solution and stirring continued at 20-25¡ã C. for 2 hr to obtain solution A.In another round bottom flask, 6,7-dimethoxy-2-(piperazin-1-yl)quinazolin-4-amine (0.346 mol; 100 g) and tetrahydrofuran (1000 ml) were charged and stirred at 26-28¡ã C. for 5-10 min to obtain a slurry.Solution A was added dropwise within 2-2.5 hr at 25-28¡ã C. to the slurry.The reaction was monitored by HPLC.To the resulting clear reaction mass charcoal was added and contents were stirred at 26-28¡ã C. for 45 min.The contents were filtered through celite and washed with tetrahydrofuran.The solvent was distilled out at 35¡ã C. under reduced pressure to obtain solid residue.Acetone (1000 ml) was added to the solid and contents were refluxed for 2 hr.On cooling to 25-28¡ã C., the slurry was filtered, washed with acetone and dried at 60¡ã C. under reduced pressure to obtain 110 g of doxazosin base (HPLC purity -99.4percent).

3663-80-7, As the rapid development of chemical substances, we look forward to future research findings about 3663-80-7

Reference£º
Patent; CIPLA LIMITED; US2012/41199; (2012); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

A common heterocyclic compound, the benzodioxans compound, name is 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone,cas is 2879-20-1, mainly used in chemical industry, its synthesis route is as follows.

General procedure: To 1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)ethan-1-one(A) (1 mmol) alcohol solution (5 mL) was added substituted benzaldehyde(1 mmol). After dissolution, 50% NaOH (0.5 mL) was added. After confirming the completion of the reaction by thin layer chromatography, the sediment was filtered, washed with ethanol and dried to obtain chalcone

2879-20-1, As the rapid development of chemical substances, we look forward to future research findings about 2879-20-1

Reference£º
Article; Yang, Yu-Shun; Yang, Bing; Zou, Yan; Li, Guigen; Zhu, Hai-Liang; Bioorganic and Medicinal Chemistry; vol. 24; 13; (2016); p. 3052 – 3061;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2879-20-1,1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone,as a common compound, the synthetic route is as follows.,2879-20-1

a 2-Bromo-1-(2,3-dihydro-1,4-benzodioxin-6-yl)ethan-1-one By using 1-(2,3-dihydro-1,4-benzodioxin-6-yl)ethan-1-one (1.42 g, 7.97 mmol), the title compound was obtained as pale yellow solid by similar procedures to those of Example 38a (2.05 g, yield: 100%). 1H-NMR(CDCl3): 7.50-7.54(2H,m), 6.93(1H,m), 4.37(2H,s), 4.32-4.35(2H,m), 4.27-4.31(2H,m)

As the paragraph descriping shows that 2879-20-1 is playing an increasingly important role.

Reference£º
Patent; Yamabe, Haruko; Okuyama, Masahiro; Nakao, Akira; Ooizumi, Mitsuru; Saito, Ken-ichi; US2003/212094; (2003); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2879-20-1,1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone,as a common compound, the synthetic route is as follows.,2879-20-1

To a stirred solution of coptisine (250 mg, 0.70 mmol) in 5 N NaOH (1 ml), 6-acetyl-1,4-benzodioxane (1 mL, 6.67 mmol) was added slowly. The reaction mixture was stirred at 60 C. for 3 h. The reaction mixture was extracted with CHCl3/MeOH (v/v=10:1). The organic layer was washed to neutral with water, and dried over anhydrous MgSO4, and filtered, and then concentrated under reduced pressure to give intermediate product. The intermediate product was dissolved in anhydrous tetrahydrofuran (5 mL) followed by addition of HOAc (0.5 mL) and formaldehyde (1.5 mL, 15.06 mmol) dropwise. The reaction mixture was kept refluxing for 3 h. After the reaction completed, the reaction mixture was concentrated and added with 2 N HCl (2 mL), then stirred at room temperature for 1 h and extracted with CHCl3/MeOH (v/v=10:1). The organic layer was dried over anhydrous MgSO4 and then filtered and concentrated under reduced pressure to give crude product, which was purified via silica gel column chromatography (CHCl3/MeOH (v/v)=20:1) to give pure yellow solid (110 mg, 28.1% yield).

2879-20-1 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone 76143, abenzodioxans compound, is more and more widely used in various fields.

Reference£º
Patent; Institute of Materia Medica, Chinese Academy of Medical Sciences; Qin, Hailin; Wang, Wenjie; Zhang, Zhihui; Wu, Lianqiu; Deng, Anjun; Yu, Jinqian; Li, Zhihong; US2015/31717; (2015); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

20197-75-5, Methyl 1,4-Benzodioxan-6-carboxylate is a benzodioxans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

will be 1, 4 – benzene and dioxane -6 – methyl formate (26.0g, 133 . 9mmol) by adding acetic acid (150 ml) in, stirring to dissolve, dropping fuming nitric acid (51 ml), canada finishes, heating up to 70 ¡ãC stirring 1 hour. Cooling to room temperature, concentrated under reduced pressure, for 5percent of sodium hydroxide aqueous solution to adjust the pH to 7, adding ethyl acetate, the organic phase after the water washing, drying, concentration, be 7 – nitro – 2, 3 – dihydrobenzo [b] [1, 4] dioxin -6 – carboxylic acid methyl ester (31.1g, 97percent).

20197-75-5, 20197-75-5 Methyl 1,4-Benzodioxan-6-carboxylate 3802178, abenzodioxans compound, is more and more widely used in various fields.

Reference£º
Patent; Shanghai Huilun Life Technology Co., Ltd.; Cheng Jianjun; Qin Jihong; (25 pag.)CN104557955; (2017); B;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

3663-80-7, 2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid is a benzodioxans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,3663-80-7

0.1mol2,3-dihydrobenzo[b][1,4]dioxine-2-carboxylic acid was added to 50 mL thionyl chloride. The mixturewas refluxed for 1 hour, and then the solvent was evaporated under reducedpressure. The residue was added 150 mL hot toluene. After stirring, 100 mLtoluene was evaporated under reduced pressure, and then the residue cooled toroom temperature. 2,3-dihydrobenzo[b][1,4]dioxine-2-carbonyl chloride wasobtained after filtration

The synthetic route of 3663-80-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wang, Songlin; Chen, Yin; Zhao, Song; Xu, Xiangqing; Liu, Xin; Liu, Bi-Feng; Zhang, Guisen; Bioorganic and Medicinal Chemistry Letters; vol. 24; 7; (2014); p. 1766 – 1770;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

2879-20-1, 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone is a benzodioxans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a 38 mL pressure-resistant tube, 6-acetyl-1,4-benzodioxane (1.0 mmol), p-toluenesulfonylhydrazide (1.0 mmol), potassium thiocyanate (1.0 mmol), and iodine (2.0) were added. Methyl acetate (0.5 mmol) and 3 mL of DMSO, the mixture was stirred and heated at 130 C for 1 hour, and the reaction was monitored by thin layer chromatography (TLC) until the substrate was completely reacted and the product point was no longer changed. Stop the reaction.After the reaction was cooled to room temperature, it was poured into a saturated Na2S2O3(50 mL) solution, and extracted with EtOAc (50 mL*3). The organic phase was then poured into an Erlenmeyer flask and dried over anhydrous Na2SO4in the organic phase.After distilling off the solvent under reduced pressure, the crude product was purified by column chromatography eluting with petroleum ether and ethyl acetate to give a pale yellow solid. and the total yield 87%

2879-20-1, The synthetic route of 2879-20-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Central China Normal University; Wang Can; Geng Xiao; Wu Yandong; Wu Anxin; (11 pag.)CN110143930; (2019); A;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem