Tag: M.W=150-200

I found the field of Pharmacology & Pharmacy very interesting. Saw the article Sulfonamide-based ring-fused analogues for CAN508 as novel carbonic anhydrase. inhibitors endowed with antitumor activity: Design, synthesis, and in vitro biological evaluation published in 2020.0. Recommanded Product: 100-19-6, Reprint Addresses Eldehna, WM (corresponding author), Kafrelsheikh Univ, Fac Pharm, Dept Pharmaceut Chem, POB 33516, Kafrelsheikh, Egypt.; Supuran, CT (corresponding author), Univ Florence, Dept NEUROFARBA, Sect Pharmaceut & Nutraceut Sci, Polo Sci, Via U Schiff 6, I-50019 Florence, Italy.; Abou-Seri, SM (corresponding author), Cairo Univ, Fac Pharm, Dept Pharmaceut Chem, Kasr El Aini St,POB 11562, Cairo, Egypt.. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone

In the present study, we report the design and synthesis of novel CAN508 sulfonamide-based analogues (4, 8a-e, 9a-h and 10a-e) as novel carbonic anhydrase (CA) inhibitors with potential CDK inhibitory activity. A bioisosteric replacement approach was adopted to replace the phenolic OH of CAN508 with a sulfamoyl group to afford compound 4. Thereafter, a ring-fusion approach was utilized to furnish the 5/5 fused imidazopyrazoles 8a-e which were subsequently expanded to 6/5 pyrazolopyrimidines 9a-h and 10a-e. All the synthesized analogues were evaluated for their inhibitory activity toward isoforms hCA I, II, IX and XII. The target tumor-associated isoforms hCA IX and XII were effectively inhibited with KIs ranges 6-67.6 and 10.1-88.6 nM, respectively. Furthermore, all compounds were evaluated for their potential CDK2 and 9 inhibitory activities. Pyrazolopyrimidines 9d, 9e and 10b displayed weak CDK2 inhibitory activity (IC50 = 6.4, 8.0 and 11.6 mu M, respectively), along with abolished CDK9 inhibitory activity. This trend suggested that pyrazolopyrimidine derivatives merit further optimization to furnish more effective CDK2 inhibitor lead. On account of their excellent activity and selectivity towards hCA IX and XII, pyrazolopyrimidines 10 were evaluated for their anti-proliferative activity toward breast cancer MCF-7 and MDA-MB-468 cell lines under normoxic and hypoxic conditions. The most potent anti-proliferative agents 10a, 10c and 10d significantly increased cell percentage at sub-G1 and G2-M phases with concomitant decrease in the S phase population in MCF-7 treated cells. Finally, a docking study was undertaken to investigate the binding mode for the most selective hCA IX and XII inhibitors 10a-e, within hCA II, IX and XII active sites. (C) 2020 Elsevier Masson SAS. All rights reserved.

Welcome to talk about 100-19-6, If you have any questions, you can contact Said, MA; Eldehna, WM; Nocentini, A; Fahim, SH; Bonardi, A; Elgazar, AA; Krystof, V; Soliman, DH; Abdel-Aziz, HA; Gratteri, P; Abou-Seri, SM; Supuran, CT or send Email.. Recommanded Product: 100-19-6

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Catalytic behaviour of solid acidic SO42–SnO2-fly ash peony flower like nano catalyst on the synthesis of some E-Pyrenyl enones WOS:000640214400027 published article about SULFATED TIN OXIDE; SNO2 in [Sekar, K. G.; Janaki, P.] Natl Coll, Dept Chem, Tiruchirappalli 620001, India; [Muthuvel, I.; Thirumurthy, K.; Thirunarayanan, G.] Annamalai Univ, Dept Chem, Annamalainagar 608002, India; [Muthuvel, I.] MR Govt Arts Coll, Dept Chem, Mannargudi 614001, India; [Usha, V.] Univ Coll Engn, Dept Chem, Panruti 607106, India in 2021.0, Cited 28.0. SDS of cas: 100-19-6. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

Sulphated tin oxide-fly ash peony flower like nano catalyst was employed for the synthesis of some Epyrenyl enones by microwave irradiated Aldol condensation of various substituted acetophenones and 1-pyrenaldehyde under solvent-free conditions. About 80% yields were obtained in this protocol. Catalytic character of SO42–SnO2-fly ash peony flower was investigated using obtained yield and reusability. These E-pyrenyl enones were characterized by their melting points, CHN analysis and spectroscopic data. Also, the influence of the solvents on the yield was investigated. (C) 2020 Elsevier Ltd. All rights reserved. Selection and peer-review under responsibility of the scientific committee of the International Conference on Advanced Materials Behavior and Characterization.

SDS of cas: 100-19-6. Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Bilgicli, HG; Burhan, H; Diler, F; Cellat, K; Kuyuldar, E; Zengin, M; Sen, F in [Bilgicli, Hayriye Genc; Diler, Fatma; Zengin, Mustafa] Sakarya Univ, Fac Arts & Sci, Dept Chem, Esentepe Campus, TR-54187 Serdivan, Sakarya, Turkey; [Burhan, Hakan; Cellat, Kemal; Kuyuldar, Esra; Sen, Fatih] Dumlupinar Univ, Biochem Dept, Sen Res Grp, Fac Arts & Sci, Evliya Celebi Campus, TR-43100 Kiltahya, Turkey published Composites of palladium nanoparticles and graphene oxide as a highly active and reusable catalyst for the hydrogenation of nitroarenes in 2020.0, Cited 48.0. Computed Properties of C8H7NO3. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

Herein, the composite of palladium nanoparticles and graphene oxide (CPG) has been synthesized by a facile and very efficient method that provided chemical selectivity and high catalytic activity. The synthesized CPG was characterized by several techniques such as transmission and high-resolution electron microscopy (TEM and HR-TEM), X-ray diffraction (XRD) and Raman spectroscopy, and Photoelectron spectroscopy (XPS). CPG was tested for selective reduction of nitroarenes at room temperature. After the addition of CPG to the reaction media, catalytic performances were depended upon the cooperative effect of hydrogen activation with Pd nanoparticles, where the lack of electrons favors an excellent performance. Nitroarenes can be bound to the energetically preferred adsorption site for the nitro group in electrically enriched graphene oxide. In addition, the Pd nanoparticles transfer electrons to the graphene oxide which increases the functions of metal and carbon support. CPG exhibits both chemoprotective and high catalytic performance for hydrogenation of nitroarenes at room temperature. Aniline derivatives were obtained with high yields under mild conditions and a practical catalytic system was developed by the use of CPG.

Welcome to talk about 100-19-6, If you have any questions, you can contact Bilgicli, HG; Burhan, H; Diler, F; Cellat, K; Kuyuldar, E; Zengin, M; Sen, F or send Email.. Computed Properties of C8H7NO3

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Category: benzodioxans. In 2019 ORG LETT published article about AMINO-ACIDS; REARRANGEMENT in [Jongwohan, Chanantida; Suzuki, Toshiyasu; Fujinami, Takeshi; Adachi, Kiyohiro; Momiyama, Norie] Inst Mol Sci, Okazaki, Aichi 4448787, Japan; [Jongwohan, Chanantida; Suzuki, Toshiyasu; Momiyama, Norie] SOKENDAI Grad Univ Adv Studies, Okazaki, Aichi 4448787, Japan; [Honda, Yasushi] HPC Syst Inc, West Japan Off, Shimogyo Ku, 646 Nijohanjikicho, Kyoto 6008412, Japan; [Adachi, Kiyohiro] Univ Tokyo, Sch Engn, Dept Appl Chem, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1118656, Japan in 2019, Cited 18. The Name is 2,2-Diphenylacetonitrile. Through research, I have a further understanding and discovery of 86-29-3.

The rearrangement of ene-aldimines is a useful reaction for affording homoallylic amines. Despite their utilities in synthetic chemistry, the rearrangement for accessing homoallylic amines substituted at the 2-position remains elusive. In this study, the Bronsted acid-initiated formal [1,3]-rearrangement of ene-aldimines was developed to synthesize 2,4,4-substituted homoallylic amines that were otherwise inaccessible previously. Our study reveals an intermolecular pathway in which the rearrangement proceeds via a protonation-mediated 2-azaallenium cation.

Category: benzodioxans. Bye, fridends, I hope you can learn more about C14H11N, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Ni-Au alloy nanoparticles as a high performance heterogeneous catalyst for hydrogenation of aromatic nitro compounds WOS:000467235800033 published article about CHEMOSELECTIVE HYDROGENATION; SELECTIVE HYDROGENATION; GOLD; METAL; REDUCTION; EFFICIENT; AZO in [Lang, Leiming; Pan, Zhaorui; Yan, Jun] Nanjing Xiaozhuang Univ, Lab Adv Funct Mat Nanjing, Nanjing 211171, Jiangsu, Peoples R China; [Lang, Leiming] Nanjing Univ, State Key Lab Analyt Chem Life Sci, Nanjing 210093, Jiangsu, Peoples R China in 2019.0, Cited 30.0. Recommanded Product: 1-(4-Nitrophenyl)ethanone. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

Selective hydrogenation of nitro compounds requires highly active and less expensive materials as a heterogeneous catalyst. As a good candidate, the Ni-Au alloy nanoparticles (NPs) have been synthesized by simple in-situ reduction method, which was loaded to the active carbon with 10 wt % loading amount. The Ni-Au/C catalyst shows superior catalytic performance for hydrogenation of nitro compounds with 100% conversion and selectivity without any by-products, which also indicates good recycle performance for several times use. The prepared catalyst not only reduces the usage amount of noble metal, but also keeps the high catalytic activity, which is a promising catalyst for industry applications. (C) 2019 Elsevier B.V. All rights reserved.

Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.. Recommanded Product: 1-(4-Nitrophenyl)ethanone

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article A Highly Practical Copper(II)/TEMPO-SO4H Catalyst System for Aerobic Oxidations of Primary Benzylic and Allylic Alcohols on Gram-Scale in Water WOS:000477382000001 published article about ACTIVATED DIMETHYL-SULFOXIDE; SELECTIVE OXIDATION; ALDEHYDES; TEMPO; GREEN; EFFICIENT; REAGENTS in [Chen, Tianyou; Wang, Zihao; Xiao, Juncong; Yi, Changfeng; Xu, Zushun] Hubei Univ, Hubei Collaborat Innovat Ctr Adv Organ Chem Mat, Minist Educ, Key Lab Green Preparat & Applicat Funct Mat,Sch M, Wuhan 430062, Hubei, Peoples R China; [Cao, Zheng] Changzhou Univ, Jiangsu Key Lab Environm Friendly Polymer Mat, Sch Mat Sci & Engn, Jiangsu Collaborat Innovat Ctr Photovolta Sci & E, Changzhou 213164, Peoples R China in 2019.0, Cited 47.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. SDS of cas: 100-19-6

We report a highly practical copper(II)/TEMPO-SO4H catalyst system for aerobic oxidations of primary benzylic and allylic alcohols. A higher activity was achieved when TEMPO-SO4H, an economically feasible 2,2,6,6-tetramethylpiperidinyl-1-oxyl (TEMPO) derivative containing a sulfonic acid group, was used to replace TEMPO. The use of such Cu-II/TEMPO-SO4H catalysts can significantly simplify the removal of catalysts and dramatically reduce the amount of organic solvents used. The aerobic oxidation of primary benzylic and allylic alcohols was conducted in water on gram scale using air as the oxidant, and in the absence of surfactant, leading to green catalysis.

SDS of cas: 100-19-6. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Chen, TY; Wang, ZH; Xiao, JC; Cao, Z; Yi, CF; Xu, ZS or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Formula: C8H7NO3. In 2020.0 BIOORG CHEM published article about FRUGIPERDA LEPIDOPTERA-NOCTUIDAE; INSECTICIDAL ACTIVITY; EFFLUX PUMP; SEMISYNTHESIS; DERIVATIVES; INHIBITION; PESTICIDES; MOSQUITO; AMIDES in [Tantawy, Ahmed H.; Wang, Man-Qun] Huazhong Agr Univ, Coll Plant Sci & Technol, Hubei Insect Resources Utilizat & Sustainable Pes, Wuhan 430070, Hubei, Peoples R China; [Tantawy, Ahmed H.; Jiang, Hong] Huazhong Agr Univ, Coll Sci, Dept Chem, Wuhan 430070, Hubei, Peoples R China; [Tantawy, Ahmed H.] Benha Univ, Coll Sci, Dept Chem, Banha 13518, Egypt; [Farag, Shaimaa M.] Ain Shams Univ, Dept Entomol, Fac Sci, El Abaseya, Egypt; [Hegazy, Lamees] Washington Univ, Ctr Clin Pharmacol, Sch Med, St Louis, MO 63110 USA; [Hegazy, Lamees] St Louis Coll Pharm, St Louis, MO 63110 USA in 2020.0, Cited 45.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

A series of piperine-based dienehydrazide derivatives were designed and synthesized to be used as insecticides against Culex pipiens. The chemical structure of compound 5n was confirmed by single-crystal x-ray diffraction. Their insecticidal activities of synthesized compounds were tested against third-instar larval of Cx. pipiens at concentrations ranging from 0.1 to 1.2 mg/mL. Among all derivatives, compounds 5a, 5b, 5f, 5g, 5m, 5n, 5o, 5p, and 5u displayed good activities. The final mortality rates at the concentration of 0.75 mg/mL after 48 h treatment, were found to be in the range from 80.00 to 83.33% and with LC50 values ranging from 0.221 to 0.094 mg/mL. These compounds demonstrated higher insecticidal activities than piperine and Deltamethrin (a commercial positive control). Molecular modelling reveals several molecular interactions between synthesized compounds and the substrate binding sits of acetylcholinesterase (AChE) that are predicted to be responsible for its binding and inhibition activity.

Welcome to talk about 100-19-6, If you have any questions, you can contact Tantawy, AH; Farag, SM; Hegazy, L; Jiang, H; Wang, MQ or send Email.. Formula: C8H7NO3

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Recommanded Product: 86-29-3. In 2020 ORGANOMETALLICS published article about H BOND ACTIVATION; SELECTIVE CATALYTIC-HYDROGENATION; HEXAHYDRIDE COMPLEX; LIGANDS PREPARATION; N-H; DEHYDROGENATION; HYDRIDE; VINYLIDENE; RUTHENIUM; REACTIVITY in [Babon, Juan C.; Esteruelas, Miguel A.; Lopez, Ana M.; Onate, Enrique] Univ Zaragoza CSIC, Dept Quim Inorgan, Inst Sintesis Quim & Catalisis Homogenea ISQCH, Ctr Innovac Quim Avanzada ORFEO CINQA, Zaragoza 50009, Spain in 2020, Cited 116. The Name is 2,2-Diphenylacetonitrile. Through research, I have a further understanding and discovery of 86-29-3.

The transformation of alkyl nitriles to symmetrical and asymmetrical secondary aliphatic amines promoted by the hexahydride complex OsH6 ((PPr3)-Pr-i)(2) (1) is described, and the mechanisms of the reactions involved are established. Complex 1 catalyzes the aforementioned transformations of aryl-, pyridyl-, and alkoxy-functionalized alkyl nitriles with linear or branched chains. The formation of the secondary amines involves primary imines, primary amines, and secondary imines as organic intermediates. The reactions take place under mild conditions (toluene, 100 degrees C, and 4 bar of H-2). Stoichiometric reactions of 1 with pivalonitrile and 2-methoxyacetonitrile have allowed us to isolate the trihydride azavinylidene derivatives OsH3{=N=CHR}((PPr3)-Pr-i)(2) (R = Bu-t (3), CH2OMe (4)). Their formation involves the insertion of the N-C triple bond of the substrates into an Os-H bond of the unsaturated tetrahydride OsH4 ((PPr3)-Pr-i)(2) (A), which is generated by reductive elimination of H-2 from the hexahydride precursor. The reaction of these trihydride azavinylidene species with H-2 is the key step for the reduction of the N-C triple bond of the nitriles. In the absence of H-2, the attack of A to the azavinylidene ligand produces the rupture of its C(sp(2))-C(sp(3)) bond. As a consequence of this attack and the presence of primary imines and amines in the reaction media, the binuclear complexes ((PPr3)-Pr-i)(2) H4Os(mu-CN)OsH3{kappa(1)-N-(NH= CHCH2OMe)}((PPr3)-Pr-i)(2) (5) and ((PPr3)-Pr-i)(2)H4Os(mu-CN)OsH3{kappa(1)-N-(NH2CH2CH2OMe)}((PPr3)-Pr-i)(2) (6) have been isolated and characterized by X-ray diffraction analysis, for 2-methoxyacetonitrile. DFT calculations reveal noticeable similarities between the hydrogenations of nitriles to primary imines and those of primary imines to primary amines.

About 2,2-Diphenylacetonitrile, If you have any questions, you can contact Babon, JC; Esteruelas, MA; Lopez, AM; Onate, E or concate me.. Recommanded Product: 86-29-3

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

COA of Formula: C14H11N. Recently I am researching about BOND FORMATION; HYDROXYPHTHALIMIDE SYNTHESIS; AMINO-ACIDS; ALDEHYDES; FUNCTIONALIZATION; ESTERIFICATION; DERIVATIVES; EFFICIENT; OLIGOMERIZATION; DIMERIZATION, Saw an article supported by the Russian Science FoundationRussian Science Foundation (RSF) [18-13-00027]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Krylov, IB; Lopat’eva, ER; Budnikov, AS; Nikishin, GI; Terent’ev, AO. The CAS is 86-29-3. Through research, I have a further understanding and discovery of 2,2-Diphenylacetonitrile

Cross-dehydrogenative C-O coupling of N-hydroxyimides with ketones, esters, and carboxylic acids was achieved employing the di-tertbutyl peroxide as a source of free radicals and a dehydrogenating agent. The proposed method is experimentally simple and demonstrates the outstanding efficiency for the challenging CH substrates, such as unactivated esters and carboxylic acids. It was shown that N-hydroxyphthalimide drastically affects the oxidative properties of t-BuOOt-Bu by intercepting the t-BuO center dot radicals with the formation of phthalimide-N-oxyl radicals, a species responsible for both hydrogen atom abstraction from the CH reagent and the selective formation of the C-O coupling product by selective radical cross-recombination. The practical applicability of the developed method was exemplified by the single-stage synthesis of commercial reagent (known as Baran aminating reagent precursor) from isobutyric acid and N-hydroxysuccinimide, whereas in the standard synthetic approach, four stages are necessary.

COA of Formula: C14H11N. Welcome to talk about 86-29-3, If you have any questions, you can contact Krylov, IB; Lopat’eva, ER; Budnikov, AS; Nikishin, GI; Terent’ev, AO or send Email.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Bronsted Acid-Initiated Formal [1,3]-Rearrangement Dictated by beta-Substituted Ene-Aldimines WOS:000474795200015 published article about AMINO-ACIDS; REARRANGEMENT in [Jongwohan, Chanantida; Suzuki, Toshiyasu; Fujinami, Takeshi; Adachi, Kiyohiro; Momiyama, Norie] Inst Mol Sci, Okazaki, Aichi 4448787, Japan; [Jongwohan, Chanantida; Suzuki, Toshiyasu; Momiyama, Norie] SOKENDAI Grad Univ Adv Studies, Okazaki, Aichi 4448787, Japan; [Honda, Yasushi] HPC Syst Inc, West Japan Off, Shimogyo Ku, 646 Nijohanjikicho, Kyoto 6008412, Japan; [Adachi, Kiyohiro] Univ Tokyo, Sch Engn, Dept Appl Chem, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1118656, Japan in 2019, Cited 18. The Name is 2,2-Diphenylacetonitrile. Through research, I have a further understanding and discovery of 86-29-3. HPLC of Formula: C14H11N

The rearrangement of ene-aldimines is a useful reaction for affording homoallylic amines. Despite their utilities in synthetic chemistry, the rearrangement for accessing homoallylic amines substituted at the 2-position remains elusive. In this study, the Bronsted acid-initiated formal [1,3]-rearrangement of ene-aldimines was developed to synthesize 2,4,4-substituted homoallylic amines that were otherwise inaccessible previously. Our study reveals an intermolecular pathway in which the rearrangement proceeds via a protonation-mediated 2-azaallenium cation.

HPLC of Formula: C14H11N. About 2,2-Diphenylacetonitrile, If you have any questions, you can contact Jongwohan, C; Honda, Y; Suzuki, T; Fujinami, T; Adachi, K; Momiyama, N or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem