Tag: M.W=150-200

An article Synthesis, cytotoxicity and in vitro antibacterial screening of novel hydrazones bearing thienopyridine moiety as potent COX-2 inhibitors WOS:000545550700002 published article about BIOLOGICAL EVALUATION; MOLECULAR DOCKING; DERIVATIVES; DESIGN; HYDRAZIDES; DISCOVERY; SAR in [Sanad, Sherif M. H.; Mekky, Ahmed E. M.] Cairo Univ, Fac Sci, Chem Dept, Giza 12613, Egypt in 2020.0, Cited 58.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. SDS of cas: 100-19-6

The starting precursors 2-carbohydrazides, bearing thienopyridine moiety, were prepared using 2-thioxopyridine-3-carbonitriles as key synthons. Next, 2-carbohydrazides were reacted with a variety of 4-substituted benzylidinemalononitriles or 4-substituted benzaldehydes to afford a new series of the target hydrazones incorporating thienopyridine moiety. The elemental analyses and spectral data were used to demonstrate the structures of new hydrazones series. The in vitro antibacterial activities of the target hydrazones were evaluated against different strains of Gram-positive and Gram-negative bacteria. In comparison with chloramphenicol as a reference drug, hydrazones 13b, 13c and 13d, linked to p-C1, p-Br and p-Me moiety, respectively, exhibited the strongest activities against all tested bacteria with MIC values in the range of 6.2-12.5 mu g/mL. In addition, several new hydrazones were tested as in vitro cytotoxic agents against each of human breast carcinoma MCF-7 cell line, colon cancer Caco2 cell line and liver hepatocellular carcinoma HEPG2 cell line. The hydrazones 13b, 13c and 13d demonstrated the best cytotoxicity against the tested eukaryotic cells. Furthermore, both experimental and docking studies could predict the promising inhibitory activities of hydrazones 13c and 13d against COX-2 enzyme with IC 50 of 0.110 and 0.104 mu M, respectively, when compared with Celecoxib (IC50 of 0.115 mu M). [GRAPHICS] .

SDS of cas: 100-19-6. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Sanad, SMH; Mekky, AEM or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Palladium-Catalyzed C-H Arylation of Aliphatic and Aromatic Ketones using Dipeptide Transient Directing Groups WOS:000466161500014 published article about CARBON-CARBON BONDS; C(SP(3))-H FUNCTIONALIZATION; ALDEHYDES; OSTEOARTHRITIS; NABUMETONE; ACTIVATION; MANAGEMENT; AMIDATION; SAFETY; DRUG in [Cheng, Yaohang; Zheng, Jie; Tian, Chao; He, Yuhang; Zhang, Cong; Tan, Qi; An, Guanghui; Li, Guangming] Heilongjiang Univ, Key Lab Funct Inorgan Mat Chem MOE, Sch Chem & Mat Sci, 74 Xuefu Rd, Harbin 150080, Heilongjiang, Peoples R China; [An, Guanghui] Harbin Engn Univ, Coll Mat Sci & Chem Engn, Harbin 150001, Heilongjiang, Peoples R China in 2019.0, Cited 52.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Safety of 1-(4-Nitrophenyl)ethanone

Ketones are ubiquitous structural motifs in chemical materials and medicinally active pharmaceutical ingredients. Transition metal-catalyzed C-H bond functionalization is one of the most efficient tactics for diversification of ketones. Palladium-catalyzed C-H arylation of aliphatic and aromatic ketones has been achieved utilizing an inexpensive dipeptide as a transient directing group. The tridentate coordination used in this reaction enhances the reactivity of the substrates and allows reduction of the loading of the directing group compounds to 20%. This approach allows rapid arylation of complex natural products, medicinal-chemistry-related scaffolds, and even remote C(sp(2))-H bonds.

Safety of 1-(4-Nitrophenyl)ethanone. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Cheng, YH; Zheng, J; Tian, C; He, YH; Zhang, C; Tan, Q; An, GH; Li, GM or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

In 2019.0 J ORG CHEM published article about ENANTIOSELECTIVE SYNTHESIS; TRANSFER HYDROGENATION; ALIPHATIC-KETONES; SILICON-COMPOUNDS; PENTACOORDINATE; REAGENTS; PHOSPHORUS; REACTIVITY; COMPLEXES in [Skrypai, Vladislav; Varjosaari, Sami E.; Gilbert, Thomas M.; Adler, Marc J.] Northern Illinois Univ, Dept Chem & Biochem, 1425 W Lincoln Hwy, De Kalb, IL 60115 USA; [Varjosaari, Sami E.] Coker Coll, Dept Sci & Math, 300 E Coll Ave, Hartsville, SC 29550 USA; [Azam, Fawwaz; Adler, Marc J.] Ryerson Univ, Dept Chem & Biol, 350 Victoria St, Toronto, ON M5B 2K3, Canada in 2019.0, Cited 45.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. HPLC of Formula: C8H7NO3

The asymmetric direct reductive amination of prochiral ketones with aryl amines using 1-hydrosilatrane with a chiral Bronsted acid catalyst is reported. This is the first known example of chiral Bronsted acid-catalyzed asymmetric reductive amination using a silane as the hydride source. The reaction features a highly practical reducing reagent and proceeds efficiently at room temperature without a specialized reaction setup or equipment to exclude air or moisture. This method provides high conversion and enantiomeric excess up to 84% of the desired chiral secondary amines with minimal side products.

HPLC of Formula: C8H7NO3. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Skrypai, V; Varjosaari, SE; Azam, F; Gilbert, TM; Adler, MJ or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

In 2020.0 EUR J MED CHEM published article about MITOCHONDRIAL SIRTUINS; HISTONE DEACETYLASE; STRUCTURAL BASIS; LIFE-SPAN; DESUCCINYLATION; MECHANISM; DISEASE; CANCER; GROWTH; GENE in [Glas, Carina; Urban, Lars; Bracher, Franz] Ludwig Maximilians Univ Munchen, Ctr Drug Res, Dept Pharm, Butenandtstr 5-13, D-81377 Munich, Germany; [Dietschreit, Johannes C. B.; Ochsenfeld, Christian] Ludwig Maximilians Univ Munchen, Dept Chem, Chair Theoret Chem, Butenandtstr 7, D-81377 Munich, Germany; [Woessner, Nathalie; Jung, Manfred] Albert Ludwigs Univ Freiburg, Inst Pharmaceut Sci, Albertstr 25, D-79104 Freiburg, Germany; [Ghazy, Ehab; Sippl, Wolfgang] Martin Luther Univ Halle Wittenberg, Inst Pharm, Wolfgang Langenbeck Str 4, D-06120 Halle, Saale, Germany in 2020.0, Cited 66.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Category: benzodioxans

We report here an extensive structure-activity relationship study of balsalazide, which was previously identified in a high-throughput screening as an inhibitor of Sirt5. To get a closer understanding why this compound is able to inhibit Sirt5, we initially performed docking experiments comparing the binding mode of a succinylated peptide as the natural substrate and balsalazide with Sirt5 in the presence of NAD(+). Based on the evidence gathered here, we designed and synthesized 13 analogues of balsalazide, in which single functional groups were either deleted or slightly altered to investigate which of them are mandatory for high inhibitory activity. Our study confirms that balsalazide with all its given functional groups is an inhibitor of Sirt5 in the low micromolar concentration range and structural modifications presented in this study did not increase potency. While changes on the N-aroyl-beta-alanine side chain eliminated potency, the introduction of a truncated salicylic acid part minimally altered potency. Calculations of the associated reaction paths showed that the inhibition potency is very likely dominated by the stability of the inhibitor-enzyme complex and not the type of inhibition (covalent vs. non-covalent). Further in-vitro characterization in a trypsin coupled assay determined that the tested inhibitors showed no competition towards NAD(+) or the synthetic substrate analogue ZKsA. In addition, investigations for subtype selectivity revealed that balsalazide is a subtype-selective Sirt5 inhibitor, and our initial SAR and docking studies pave the way for further optimization. (C) 2020 Elsevier Masson SAS. All rights reserved.

Category: benzodioxans. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Glas, C; Dietschreit, JCB; Wossner, N; Urban, L; Ghazy, E; Sippl, W; Jung, M; Ochsenfeld, C; Bracher, F or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Synthesis, Structure, and Biological Activity of Magnesium(II), Zinc(II), Cobalt(II), and Copper(II) Bis(4-aryl-1-ethoxy-1-oxobutane-2,4-dionates) WOS:000463631500012 published article about COMPLEXES; LIGANDS in [Kunavina, E. A.; Sizentsov, A. N.; Salikova, E. V.; Rusyaeva, M. L.; Korol’kova, D. S.] Orenburg State Univ, Pr Pobedy 13, Orenburg 460018, Russia; [Koz’minykh, V. O.] Perm State Humanitarian Pedag Univ, Sibirskaya Ul 24, Perm 614990, Russia in 2019.0, Cited 8.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Recommanded Product: 1-(4-Nitrophenyl)ethanone

The condensation of aryl methyl ketones with diethyl oxalate in the presence of metallic sodium or sodium hydride gave sodium 4-aryl-1-ethoxy-1,4-dioxobut-2-en-2-olates, and metal exchange of the latter with magnesium(II), zinc(II), cobalt(II), and copper(II) salts afforded the corresponding metal bis(4-aryl-1-ethoxy-1-oxobutane-2,4-dionates). The obtained complexes were tested for antibacterial activity against gram-positive and gram-negative bacteria by the agar diffusion method.

Recommanded Product: 1-(4-Nitrophenyl)ethanone. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Kunavina, EA; Koz’minykh, VO; Sizentsov, AN; Salikova, EV; Rusyaeva, ML; Korol’kova, DS or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article A near-infrared fluorescent probe for endogenous hydrogen peroxide real-time imaging in living cells and zebrafish WOS:000463979700066 published article about HIGHLY SELECTIVE DETECTION; OXIDATIVE STRESS; BORONATE; H2O2; GLUTATHIONE; CANCER in [Huang, Xin; Li, Zhipeng; Liu, Zixin; Zeng, Chengchu; Hu, Liming] Beijing Univ Technol, Beijing Key Lab Environm & Oncol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China in 2019.0, Cited 44.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Recommanded Product: 1-(4-Nitrophenyl)ethanone

Hydrogen peroxide (H2O2) can be produced in mitochondria and plays a significant role in physiological metabolism. Overproduction of H2O2 is a hallmark of many diseases. Therefore, it is very important to develop a highly sensitive method for detecting H2O2 both in vivo and in vitro. Previously reported benzil-based fluorescence probes are superior to those based on boronate ester in terms of reaction selectivity. However, the near infrared (NIR) probe with biocompatibility has been rarely reported for the detection of endogenous hydrogen peroxide and the real-time imaging in biological system. Hemicyanine skeleton has been proven to be effective scaffold for NM fluorescent probes for non-invasive optical imaging in vivo. In this paper, a Cy-H2O2 probe for real-time monitoring hydrogen peroxide in organisms was designed by modifying the NIR hemicyanine framework with benzil moiety. The results showed that Cy-H2O2 exhibits high specificity and sensitivity, and has good water solubility and short response time (within 10 min) for detection of hydrogen peroxide in vitro and in vivo. The reaction mechanism was deduced by detecting product of the fluorescent probe reacting with hydrogen peroxide using HPLC. The probe shows a good linear relationship for the specific response to H2O2 within the concentration range of 0-7 mu M and the detection limit is 65 nM. In addition, the probe Cy-H2O2 has been successfully applied to H2O2 detection in living cells and zebrafish.

Recommanded Product: 1-(4-Nitrophenyl)ethanone. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Huang, X; Li, ZP; Liu, ZX; Zeng, CC; Hu, LM or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

In 2020 EUR J ORG CHEM published article about REDUCTIVE ELIMINATION; CARBON-CARBON; NITRILES; CYANOACETATE; HALIDES; LIGAND; HETEROARYL; COMPLEXES; EFFICIENT; ACETONE in [Yuen, On Ying; Chen, Xiangmeng; Wu, Junyu; So, Chau Ming] Hong Kong Polytech Univ, State Key Lab Chem Biol & Drug Discovery, Hung Hom, Kowloon, Hong Kong, Peoples R China; [Yuen, On Ying; Chen, Xiangmeng; Wu, Junyu; So, Chau Ming] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hung Hom, Kowloon, Hong Kong, Peoples R China; [So, Chau Ming] Hong Kong Polytech Univ, Shenzhen Res Inst, Shenzhen, Peoples R China in 2020, Cited 49. The Name is 2,2-Diphenylacetonitrile. Through research, I have a further understanding and discovery of 86-29-3. Safety of 2,2-Diphenylacetonitrile

The first general palladium-catalyzed alpha-arylation of arylacetonitriles with aryl and heteroaryl sulfonates are reported. Pd(OAc)(2) associated with XPhos serves as the effective catalyst to facilitate this reaction. A broad range of electron-rich, -neutral, -deficient, and sterically hindered aryl/heteroaryl tosylates and mesylates are coupled with arylacetonitriles bearing different substituents to give the corresponding products in good to excellent yields. Catalyst loading down to 0.1 mol-% Pd was achieved, and 22 unprecedented compounds were synthesized from 43 demonstrated examples using this method. Its applicability with the modification of biological phenolic compounds was successfully demonstrated. The Pd/XPhos system catalyzed the alpha-arylation and followed by alkylation in one-pot sequential conditions, resulting in the direct synthesis of compounds containing quaternary center- and deuterium-containing compounds in good to excellent yields.

Safety of 2,2-Diphenylacetonitrile. About 2,2-Diphenylacetonitrile, If you have any questions, you can contact Yuen, OY; Chen, XM; Wu, JY; So, CM or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Recently I am researching about PALLADIUM-CATALYZED 1,4-DIFUNCTIONALIZATION; LIGHT PHOTOREDOX CATALYSIS; CROSS-COUPLING REACTIONS; CARBON BOND FORMATION; DOMINO REACTIONS; HECK REACTION; C-C; CONJUGATED DIENES; ATOM-TRANSFER; HALIDES, Saw an article supported by the Alexander von Humboldt FoundationAlexander von Humboldt Foundation; Deutsche Forschungsgemeinschaft (Leibniz Award)German Research Foundation (DFG) [SBF 858]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Huang, HM; Bellotti, P; Pfluger, PM; Schwarz, JL; Heidrich, B; Glorius, F. The CAS is 86-29-3. Through research, I have a further understanding and discovery of 2,2-Diphenylacetonitrile. Formula: C14H11N

Developing efficient and selective strategies to approach complex architectures containing (multi)stereogenic centers has been a long-standing synthetic challenge in both academia and industry. Catalytic cascade reactions represent a powerful means of rapidly leveraging molecular complexity from simple feedstocks. Unfortunately, carrying out cascade Heck-type reactions involving unactivated (tertiary) alkyl halides remains an unmet challenge owing to unavoidable beta-hydride elimination. Herein, we show that a modular, practical, and general palladium-catalyzed, radical three-component coupling can indeed overcome the aforementioned limitations through an interrupted Heck/allylic substitution sequence mediated by visible light. Selective 1,4-difunctionalization of unactivated 1,3-dienes, such as butadiene, has been achieved by employing different commercially available nitrogen-, oxygen-, sulfur-, or carbon-based nucleophiles and unactivated alkyl bromides (>130 examples, mostly >95:5 E/Z, >20:1 a). Sequential C(sp(3))-C(sp(3)) and C-X (N, O, S) bonds have been constructed efficiently with a broad scope and high functional group tolerance. The flexibility and versatility of the strategy have been illustrated in a gram-scale reaction and streamlined syntheses of complex ether, sulfone, and tertiary amine products, some of which would be difficult to access via currently established methods.

About 2,2-Diphenylacetonitrile, If you have any questions, you can contact Huang, HM; Bellotti, P; Pfluger, PM; Schwarz, JL; Heidrich, B; Glorius, F or concate me.. Formula: C14H11N

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

I found the field of Chemistry very interesting. Saw the article Simple RuCl3-catalyzed N-Methylation of Amines and Transfer Hydrogenation of Nitroarenes using Methanol published in 2021.0. Product Details of 100-19-6, Reprint Addresses Natte, K (corresponding author), CSIR Indian Inst Petr, Chem & Mat Sci Div, Haridwar Rd, Dehra Dun 248005, Uttarakhand, India.; Natte, K (corresponding author), Acad Sci & Innovat Res AcSIR, CSIR HRDC Campus,Joggers Rd, Ghaziabad 201002, Uttar Pradesh, India.. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone

Methanol is a potential hydrogen source and C-1 synthon, which finds interesting applications in both chemical synthesis and energy technologies. The effective utilization of this simple alcohol in organic synthesis is of central importance and attracts scientific interest. Herein, we report a clean and cost-competitive method with the use of methanol as both C-1 synthon and H-2 source for selective N-methylation of amines by employing relatively cheap RuCl3.xH(2)O as a ligand-free catalyst. This readily available catalyst tolerates various amines comprising electron-deficient and electron-donating groups and allows them to transform into corresponding N-methylated products in moderate to excellent yields. In addition, few marketed pharmaceutical agents (e. g., venlafaxine and imipramine) were also successfully synthesized via late-stage functionalization from readily available feedstock chemicals, highlighting synthetic value of this advanced N-methylation reaction. Using this platform, we also attempted tandem reactions with selected nitroarenes to convert them into corresponding N-methylated amines using MeOH under H-2-free conditions including transfer hydrogenation of nitroarenes-to-anilines and prepared drug molecules (e. g., benzocaine and butamben) as well as key pharmaceutical intermediates. We further enable one-shot selective and green syntheses of 1-methylbenzimidazole using ortho-phenylenediamine (OPDA) and methanol as coupling partners.

Product Details of 100-19-6. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Sarki, N; Goyal, V; Tyagi, NK; Puttaswamy; Narani, A; Ray, A; Natte, K or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Quality Control of 1-(4-Nitrophenyl)ethanone. Bento, I; Bernaldez, M; Noguchi, R; Kawakami, J in [Bento, Ian; Bernaldez, Mabel; Noguchi, Ryden; Kawakami, Joel] Chaminade Univ Honolulu, Nat Sci & Math, Honolulu, HI 96816 USA published Ultrasound-assisted rapid reduction of nitroaromatics to anilines using gallium metal in 2020.0, Cited 12.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

The reduction of nitroaromatic compounds to anilines is widely used throughout organic synthesis. Typical methods of performing this transformation utilize hydrogenation over a pyrophoric catalyst or a finely divided reducing metal, which often affords heterogeneous mixtures that are difficult to purify. Herein, we report for the first time the use of gallium metal as a reducing agent in organic synthesis. The reaction proceeds under aerobic conditions and affords homogeneous mixtures for a convenient workup. Using this method, twelve anilines were obtained in 33% to quantitative yields with short reaction times of 10-60 minutes.

Quality Control of 1-(4-Nitrophenyl)ethanone. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Bento, I; Bernaldez, M; Noguchi, R; Kawakami, J or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem