Tag: M.W=150-200

In 2019.0 BIOORG CHEM published article about PROLIFERATOR-ACTIVATED RECEPTORS; CYCLOOXYGENASE-2 INHIBITORS; MOLECULAR DOCKING; INFLAMMATION; GLUCOSIDASE; REGULATOR; DISCOVERY; ANALOGS; RAT in [Abdellatif, Khaled R. A.; Fadaly, Wael A. A.] Beni Suef Univ, Fac Pharm, Pharmaceut Organ Chem Dept, Bani Suwayf, Egypt; [Abdellatif, Khaled R. A.] Ibn Sina Natl Coll Med Studies, Pharmaceut Sci Dept, Jeddah 21418, Saudi Arabia; [Kamel, Gehan M.] Cairo Univ, Fac Vet, Pharmacol Dept, Cairo, Egypt; [Elshaier, Yaseen A. M. M.] Al Azhar Univ, Pharmaceut Organ Chem Dept, Fac Pharm, Assiut 71524, Egypt; [El-Magd, Mohammed A.] Kafrelshiekh Univ, Anat Dept, Fac Vet Med, Kafrelshiekh 33516, Egypt in 2019.0, Cited 51.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Formula: C8H7NO3

Nowadays, diabetes and its associated inflammatory complications are important public health problems worldwide. Market limitations of drugs with dual actions as anti-inflammatory (AI) and anti-diabetic have been led to a temptation for focusing on the discovery and development of new compounds with potential AI and antidiabetic activities. Herein, we synthesized two new series containing pyrazole ring with vicinal diaryl rings as selective COX-2 moiety and thiazolidindione (series 12a-f) or thiazolidinone (series 13a-f) as anti-diabetic moiety and the two moieties were linked together with methylene or methylenehydrazone functionality. The two series were evaluated for their COX inhibition, AI activity and ulcerogenic liability and for the anti-diabetic activity; 12a-f and 13a-f were assessed in vitro against alpha-glucosidase, beta-glucosidase, in vivo hypoglycemic activity (one day and 15 days studies) in addition to PPAR. activation study. Four compounds (12c, 12f, 13b and 13f) had higher COX-2 S.I. (8.69-9.26) than the COX-2 selective drug celecoxib (COX-2 S.I. = 8.60) and showed the highest AI activities and the lowest ulcerogenicity than other derivatives. Also, two thiazolidindione derivatives 12e and 12f and two thiazolidinone derivatives 13b and 13c showed higher inhibitory activities against alpha- and beta-glucosidase (% inhibitory activity = 62.15, 55.30, 65.37, 59.08 for alpha-glucosidase and 57.42, 60.07, 58.19, 66.90 for beta-glucosidase respectively) than reference compounds (acarbose with % inhibitory activity = 49.50 for alpha-glucosidase and D-saccharic acid 1,4-lactone monohydrate with % inhibitory activity = 53.42 for beta-glucosidase) and also showed good PPAR-gamma activation and good hypoglycemic effect in comparison to pioglitazone and rosiglitazone. Moreover, Shape comparison and docking studies were carried out to understand their interaction and similarity with standard drugs.

Formula: C8H7NO3. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Abdellatif, KRA; Fadaly, WAA; Kamel, GM; Elshaier, YAMM; El-Magd, MA or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Authors Rana, M; Arif, R; Khan, FI; Maurya, V; Singh, R; Faizan, MI; Yasmeen, S; Dar, SH; Alam, R; Sahu, A; Ahmad, T; Rahisuddin in ACADEMIC PRESS INC ELSEVIER SCIENCE published article about in [Rana, Manish; Arif, Rizwan; Yasmeen, Shama; Dar, Sajad Hussain; Rahisuddin] Jamia Millia Islamia, Dept Chem, New Delhi 110025, India; [Khan, Faez Iqbal] Univ Elect Sci & Technol China, Sch Elect Sci & Engn, Chengdu, Peoples R China; [Maurya, Vikas; Singh, Raja] Jawharlal Nehru Univ, Special Ctr Mol Med, New Delhi 110067, India; [Faizan, Md Imam; Ahmad, Tanveer] Jamia Millia Islamia, Multidisciplinary Ctr Adv Res & Studies, New Delhi 110025, India; [Alam, Raquib] Jamia Millia Islamia, Univ Polytech, Dept Appl Sci, New Delhi 110025, India; [Sahu, Ankita] Safdarjung Hosp Campus, ICMR Natl Inst Pathol, New Delhi 110029, India in 2021.0, Cited 77.0. Safety of 1-(4-Nitrophenyl)ethanone. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

N-formyl pyrazoline derivatives (3a-3l) were designed and synthesized via Michael addition reaction through cyclization of chalcones with hydrazine hydrate in presence of formic acid. The structural elucidation of N-formyl pyrazoline derivatives was carried out by various spectroscopic techniques such as H-1, C-13 NMR, FT-IR, UV-visible spectroscopy, mass spectrometry and elemental analysis. Anticancer activity of the pyrazoline derivatives (3a-3l) was evaluated against human lung cancer (A549), fibrosarcoma cell lines (HT1080) and human primary normal lung cells (HFL-1) by MTT assay. The results of anticancer activity showed that potent analogs 3b and 3d exhibited promising activity against A549 (IC50 = 12.47 +/- 1.08 and 14.46 +/- 2.76 mu M) and HT1080 (IC50 = 11.40 +/- 0.66 and 23.74 +/- 13.30 mu M) but low toxic against the HFL-1 (IC50 =116.47 +/- 43.38 and 152.36 +/- 22.18 mu M). The anticancer activity of potent derivatives (3b and 3d) against A549 cancer cell line was further confirmed by flow cytometry based approach. DNA binding interactions of the pyrazoline derivatives 3b and 3d have been carried out with calf thymus DNA (Ct-DNA) using absorption, fluorescence and viscosity measurements, circular dichroism and cyclic voltammetry. Antioxidant potential of N-formyl pyrazoline derivatives (3a-3l) has been also estimated through DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical and H2O2. Results revealed that all the compounds exhibited significant antioxidant activity. In silico molecular modelling and ADMET properties of pyrazoline derivatives were also studied using PyRx software against topoisomerase II receptor with PDB ID: 1ZXM to explore their best hits. MD simulation of 3b and 3d was also carried out with topoisomerase II for structure-function correlation in a protein. HuTopoII inhibitory activity of the analogs (3a-3l) was examined by relaxation assay at varying concentrations 100-1000 mu M.

Safety of 1-(4-Nitrophenyl)ethanone. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Rana, M; Arif, R; Khan, FI; Maurya, V; Singh, R; Faizan, MI; Yasmeen, S; Dar, SH; Alam, R; Sahu, A; Ahmad, T; Rahisuddin or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Authors Monsen, PJ; Luzzio, FA in PERGAMON-ELSEVIER SCIENCE LTD published article about PORPHYROMONAS-GINGIVALIS ADHERENCE; 1,2,3-TRIAZOLE-BASED INHIBITORS; ORAL STREPTOCOCCI; PROSTAGLANDINS in [Monsen, Paige J.; Luzzio, Frederick A.] Univ Louisville, Dept Chem, 2320 South Brook St, Louisville, KY 40292 USA in 2020, Cited 25. Formula: C8H7NO3. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

An array of arylnitro compounds with various functionality were treated with freshly-prepared aluminum amalgam in THE/water solution and resulted in the corresponding arylamines. The Al(Hg)-mediated reductions are relatively rapid with consumption of the amalgam and disappearance of starting material occurring over 20-30 min. The workup of the reductions involves only removal of the insoluble by-products by filtration followed by concentration. Only in some cases is chromatography required to secure the pure product. The desired arylamines are furnished in quantities of 25-100 mg, which in some cases, could be taken on to the next reaction without further purification. Reductions of 4-nitrobenzyl derivatives of carbohydrates or nucleosides were selective in affording the corresponding 4-aminobenzyl products. To show applicability in click chemistry, selected aminobenzyl products are directly azidated to yield products that were then used in click reactions to afford the corresponding 1,2,3-triazoles. (C) 2020 Elsevier Ltd. All rights reserved.

About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Monsen, PJ; Luzzio, FA or concate me.. Formula: C8H7NO3

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

In 2019 ACS CATAL published article about AMINATION in [Chen, Wei; Chen, Kai; Chen, Wanzhi] Zhejiang Univ, Dept Chem, 38 Zheda Rd, Hangzhou 310027, Peoples R China; [Liu, Miaochang; Wu, Huayue] Wenzhou Univ, Coll Chem & Mat Engn, 588 New Chaoyang St, Wenzhou 325027, Peoples R China in 2019, Cited 33. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. SDS of cas: 100-19-6

The C-N bond formation is one of the fundamental reactions in organic chemistry, because of the widespread presence of amine moieties in pharmaceuticals and biologically active compounds. Palladium-catalyzed C-N coupling of haloarenes represents one of the most efficient approaches to aromatic amines. Nitroarenes are ideal alternative electrophilic coupling partners, since they are inexpensive and readily available. The denitration and cross-coupling using nitroarenes as the electrophilic partners is challenging, because of the low reactivity of the Ar-NO2 bond toward oxidative addition. We report here the C-N coupling of nitroarenes and amines using palladium/5-(2,4,6-triisopropylphenyl)imidazolylidene[1,5-a]pyridines as the catalyst. The ligands are readily available from commercial chemicals. The reaction shows broad substrate scope and functional group tolerance. The method is applicable to both aromatic and aliphatic amines, and many secondary and tertiary aromatic amines bearing various functional groups were obtained in high yields.

SDS of cas: 100-19-6. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Chen, W; Chen, K; Chen, WZ; Liu, MC; Wu, HY or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

SDS of cas: 100-19-6. Bahrami, K; Khodaei, MM; Batooie, N; Hosseinzadeh, N; Foroumadi, A in [Bahrami, Kiumars; Khodaei, Mohammad M.; Batooie, Nasim] Razi Univ, Fac Chem, Dept Organ Chem, Kermanshah 6714967346, Iran; [Hosseinzadeh, Nouraddin] Sharif Univ Technol, Dept Chem, Lab Organ Synth & Nat Prod, Azadi St,POB 11155-9516, Tehran, Iran; [Foroumadi, Alireza] Univ Tehran Med Sci, Fac Pharm, Dept Med Chem, Tehran, Iran published Hexyltriphenylphosphonium Bromide as an Absolutely Chemoselective Ionic Liquid Catalyst in the Three-Component Reaction of Aryl Aldehydes, Acetophenones and Malononitrile in 2019.0, Cited 44.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

Hexyltriphenylphosphonium bromide (HTPB) is used as an efficient ionic liquid catalyst in the chemoselective addition of malononitrile to carbonyl group moiety of chalcones through the three-component reaction of aryl aldehydes, acetophenone derivatves, and malononitrile to produce (E)-2-(1,3-diarylallylidene)malononitriles at ambient temperature. The method is simple, solvent-free, environmentally friendly, and gives excellent yields in a short reaction times.

SDS of cas: 100-19-6. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Bahrami, K; Khodaei, MM; Batooie, N; Hosseinzadeh, N; Foroumadi, A or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

I found the field of Chemistry very interesting. Saw the article Synthesis, Spectroscopic Characterization, DFT Calculations and Preliminary Antifungal Activity of New Piperine Derivatives published in 2021.0. Category: benzodioxans, Reprint Addresses Barbosa, JM (corresponding author), Univ Fed Paraiba, Dept Ciencias Farmaceut, BR-58051900 Joao Pessoa, PB, Brazil.. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone

Four new piperine derivatives, PC1-PC4, were synthesized, and their structures were fully characterized by infrared (IR) and H-1 and C-13 nuclear magnetic resonance (NMR) spectroscopies. Quantum chemical calculations were performed using density functional theory (DFT) with the B3LYP-D3/6-31G(d,p) and 6-311+G(2d,p) basis sets. Electronic properties, such as the energy gap between the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO) and some global chemical reactivity descriptors, were evaluated to study the reactivity and stability of the compounds. H-1 and C-13 NMR chemical shifts were calculated by using the gauge-invariant atomic orbital (GIAO) method and compared with experimental values. In addition, the compounds were evaluated in an antifungal study against Candida, Trichophyton and Microsporum strains, and only PC4 showed 70% inhibition in ten tested strains, with a minimum inhibitory concentration (MIC) ranging from 1.23-2.46 mu mol mL(-1) and a minimum fungicide concentration (MFC) ranging from 9.84-19.68 mu mol mL(-1), and presented a fungistatic effect.

Category: benzodioxans. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Souza, JS; Martins, EPS; Souza, HDS; de Oliveira, RF; Alves, FS; Lima, EO; Cordeiro, LV; Trindade, EO; Lira, BF; Rocha, GB; de Athayde, PF; Barbosa, JM or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Recommanded Product: 1-(4-Nitrophenyl)ethanone. I found the field of Chemistry very interesting. Saw the article Palladium/Acid Relay Catalyzed Tandem Heck Coupling/6-Endo Cyclization between ortho-Halogenated Benzoates and Unactivated Terminal Alkenes for the Synthesis of 1-Isochromanones published in 2019.0, Reprint Addresses Wen, ZK (corresponding author), Shanxi Univ, Sch Chem & Chem Engn, Taiyuan 030006, Shanxi, Peoples R China.. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone.

We report a unique and expeditious route to synthesize 1-isochromanone derivatives through palladium catalyzed tandem Heck coupling/6-endo hydroacyloxylation cyclization between readily available ortho-halogenated benzoates and unactivated alkenes. Various 2-bromo or 2-iodo benzoates can be coupled efficiently with a broad range of alkenes to afford functionalized 1-isochromanones in high yields. Significantly, this cost-efficient and easy-to-handle synthetic methodology will have great prospect application in the synthetic and medicinal chemistry.

Recommanded Product: 1-(4-Nitrophenyl)ethanone. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Wen, ZK; Ge, XM; Zhao, ZK; Chao, JB or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

In 2019.0 J CATAL published article about DRUG-DELIVERY SYSTEM; PHOTOREDOX CATALYSIS; HYDROGEN-PRODUCTION; METAL-COMPLEXES; ALKYLATION; ORGANOCATALYSIS; PHOTOOXIDATION; CHALLENGES; OXIDATION; DRIVEN in [Gonzalez-Munoz, Daniel; Casado-Sanchez, Antonio; Aleman, Jose] Univ Autonoma Madrid, Sci Fac, Organ Chem Dept, E-28049 Madrid, Spain; [del Hierro, Isabel; Gomez-Ruiz, Santiago] Univ Rey Juan Carlos, Escuela Super Ciencias Expt & Tecnol, Dept Biol & Geol Fis & Quim Inorgan, Madrid 28933, Spain; [Cabrera, Silvia] Univ Autonoma Madrid, Sci Fac, Inorgan Chem Dept, E-28049 Madrid, Spain; [Cabrera, Silvia; Aleman, Jose] Univ Autonoma Madrid, Inst Adv Res Chem Sci IAdChem, E-28049 Madrid, Spain in 2019.0, Cited 43.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Product Details of 100-19-6

The grafting of a Pt(II) photocatalyst into three different mesoporous silica-based materials with different particle sizes and pore sizes was easily achieved through an amide bond formation. The analysis and results of the different characterization techniques showed that the catalyst is immobilized inside the pores of the materials and the photophysical properties of the catalyst are preserved after the covalent anchoring. The photocatalytic material catalyzed efficiently the debromination reaction of different substrates and is reused without detriment in its catalytic activity. In addition, the incorporation of the catalyst into mesoporous silica materials with different pore size allows the selective debromination of substrates by size discrimination. (C) 2019 Elsevier Inc. All rights reserved.

About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Gonzalez-Munoz, D; Casado-Sanchez, A; del Hierro, I; Gomez-Ruiz, S; Cabrera, S; Aleman, J or concate me.. Product Details of 100-19-6

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

I found the field of Chemistry very interesting. Saw the article Three-Component, Interrupted Radical Heck/Allylic Substitution Cascade Involving Unactivated Alkyl Bromides published in 2020. Computed Properties of C14H11N, Reprint Addresses Glorius, F (corresponding author), Westfalische Wilhelms Univ Munster, Organ Chem Inst, D-48149 Munster, Germany.. The CAS is 86-29-3. Through research, I have a further understanding and discovery of 2,2-Diphenylacetonitrile

Developing efficient and selective strategies to approach complex architectures containing (multi)stereogenic centers has been a long-standing synthetic challenge in both academia and industry. Catalytic cascade reactions represent a powerful means of rapidly leveraging molecular complexity from simple feedstocks. Unfortunately, carrying out cascade Heck-type reactions involving unactivated (tertiary) alkyl halides remains an unmet challenge owing to unavoidable beta-hydride elimination. Herein, we show that a modular, practical, and general palladium-catalyzed, radical three-component coupling can indeed overcome the aforementioned limitations through an interrupted Heck/allylic substitution sequence mediated by visible light. Selective 1,4-difunctionalization of unactivated 1,3-dienes, such as butadiene, has been achieved by employing different commercially available nitrogen-, oxygen-, sulfur-, or carbon-based nucleophiles and unactivated alkyl bromides (>130 examples, mostly >95:5 E/Z, >20:1 a). Sequential C(sp(3))-C(sp(3)) and C-X (N, O, S) bonds have been constructed efficiently with a broad scope and high functional group tolerance. The flexibility and versatility of the strategy have been illustrated in a gram-scale reaction and streamlined syntheses of complex ether, sulfone, and tertiary amine products, some of which would be difficult to access via currently established methods.

About 2,2-Diphenylacetonitrile, If you have any questions, you can contact Huang, HM; Bellotti, P; Pfluger, PM; Schwarz, JL; Heidrich, B; Glorius, F or concate me.. Computed Properties of C14H11N

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

In 2019.0 GREEN CHEM published article about MOLECULAR-OXYGEN; SELECTIVE OXIDATION; BENZYLIC ALCOHOLS; BUILDING-BLOCKS; METAL-CATALYSTS; ALDEHYDES; MILD; POLYOXOMETALATE; KETONES; GREEN in [Wei, Zheyu; Ru, Shi; Zhao, Qixin; Yu, Han] Shanghai Inst Technol, Sch Chem & Environm Engn, 100 Haiquan Rd, Shanghai 201418, Peoples R China; [Yu, Han; Wei, Yongge] Tsinghua Univ, Dept Chem, Key Lab Organ Optoelect & Mol Engn, Minist Educ, Beijing 100084, Peoples R China; [Zhang, Gang] Sichuan Univ, Inst Mat Sci & Technol, Chengdu 610064, Sichuan, Peoples R China; [Zhang, Gang] Sichuan Univ, Analyt & Testing Ctr, Chengdu 610064, Sichuan, Peoples R China in 2019.0, Cited 66.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Name: 1-(4-Nitrophenyl)ethanone

The oxidation of alcohols to aldehydes or ketones is a highly relevant conversion for the pharmaceutical and fine-chemical industries, and for biomass conversion, and is commonly performed using stoichiometric amounts of highly hazardous oxidants. The aerobic oxidation of alcohols with transition metal complex catalysts previously required complicated organic ligands and/or nitroxyl radicals as co-catalysts. Herein, we report an efficient and eco-friendly method to promote the aerobic oxidation of alcohols using an inorganic-ligand supported copper catalyst 1, (NH4)(4)[CuMo6O18(OH)(6)], with O-2 (1 atm) as the sole oxidant. Catalyst 1 is synthesized directly from cheap and commonly available (NH4)(6)Mo7O24 center dot 4H(2)O and CuSO4, which consists of a pure inorganic framework built from a central Cu-II core supported by six (MoO6)-O-VI inorganic scaffolds. The copper catalyst 1 exhibits excellent selectivity and activity towards a wide range of substrates in the catalytic oxidation of alcohols, and can avoid the use of toxic oxidants, nitroxyl radicals, and potentially air/moisture sensitive and complicated organic ligands that are not commercially available. Owing to its robust inorganic framework, catalyst 1 shows good stability and reusability, and the catalytic oxidation of alcohols with catalyst 1 could be readily scaled up to gram scale with little loss of catalytic activity, demonstrating great potential of the inorganic-ligand supported Cu catalysts in catalytic chemical transformations.

About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Wei, ZY; Ru, S; Zhao, QX; Yu, H; Zhang, G; Wei, YG or concate me.. Name: 1-(4-Nitrophenyl)ethanone

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem