Recently I am researching about ANTIDIABETIC ACTIVITY; DERIVATIVES; AGENTS; DISCOVERY; EFFICIENT; DOCKING; ACID, Saw an article supported by the Council of Scientific and Industrial Research (CSIR)Council of Scientific & Industrial Research (CSIR) – India [02(0300)/17/EMR-II]; MHRD, India; CSIR-IICT Hyderabad Communication [IICT/Pubs/2019/332]. Published in ACADEMIC PRESS INC ELSEVIER SCIENCE in SAN DIEGO ,Authors: Pogaku, V; Gangarapu, K; Basavoju, S; Tatapudi, KK; Katragadda, SB. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone. COA of Formula: C8H7NO3
The aim of the present study is to design and synthesis of new pyrazole-triazolopyrimidine hybrids as potent alpha-glucosidase inhibitors. The target compounds 4a-n were synthesized by one-pot multicomponent approach with good yields and were characterized by various spectroscopic techniques and finally by single crystal X-ray diffraction method (4j). All the newly-synthesized derivatives have been screened for their alpha-glucosidase enzyme inhibition activity and acarbose taken as a standard drug. Among all the tested compounds, 4h has displayed excellent alpha-glucosidase enzyme inhibition activity with IC50 value 12.45 mu M to the standard drug acarbose (IC50: 12.68 mu M). Similarly, the compounds 4f and 4l have exhibited potent activity with IC50 values 14.47 mu M and 17.27 mu M respectively. Structure-activity relationship (SAR) studies of all the title compounds were established. The mode of binding interactions between the alpha-glucosidase enzyme and the compounds were studied. The drug-likeness properties (Lipinski parameters and in silico ADME properties) have predicted for the target compounds. The alpha-glucosidase inhibition, molecular docking and drug-likeness properties of the compounds 4h, 4f and 4l were suggested that these are promising hits for anti-diabetic activity.
Welcome to talk about 100-19-6, If you have any questions, you can contact Pogaku, V; Gangarapu, K; Basavoju, S; Tatapudi, KK; Katragadda, SB or send Email.. COA of Formula: C8H7NO3
Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem