Application In Synthesis of 1-(4-Nitrophenyl)ethanone. Recently I am researching about ENOYL-ACP REDUCTASE; BIOLOGICAL EVALUATION; TRIAZOLE DERIVATIVES; GALAHAD; AGENTS; DOCKING; DESIGN; BM212, Saw an article supported by the Indian Council of Medical Research, New DelhiIndian Council of Medical Research (ICMR) [BIC/12(13)2014]. Published in SPRINGER BIRKHAUSER in NEW YORK ,Authors: Joshi, SD; Kumar, SRP; Patil, S; Vijayakumar, M; Kulkarni, VH; Nadagouda, MN; Badiger, AM; Lherbet, C; Aminabhavi, TM. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone
Substituted phenylthiazolyl benzamide and pyrrolyl benzamide derivatives were developed using molecular hybridization technique to create novel lead antimycobacterial molecules used to fight against Mycobacteriumtuberculosis. The newly synthesized molecules have inhibited InhA, the enoyl-ACP reductase enzyme from the mycobacterial type II fatty acid biosynthetic pathway. Of these, compound 3b showed H-bonding interactions with Tyr158 and co-factor NAD(+) that binds the active site of InhA. All the molecules were screened for in vitro antitubercular activity against M. tuberculosis H(37)Rv, as well as some representative molecules as the inhibitors of InhA. Thirteen compounds exhibited good anti-TB activities (MIC = 1.6 mu g/mL), but only few representative molecules showed the moderate InhA enzyme inhibition activity. Basic core moiety and docked mode of all the synthesized compounds inside the proposed binding pocket of InhA with the final selected pharmacophore model molecular alignment for InhA receptor ligands. [GRAPHICS] .
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Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem