Authors Zhang, Y; Fu, X; Yan, YT; Liu, JB in WILEY published article about MUSHROOM TYROSINASE; CRYSTAL-STRUCTURE; ANTIMICROBIAL ACTIVITY; ANTI-TYROSINASE; MECHANISM; DESIGN; ACID; ANTIBACTERIAL; ANTITUMOR; DOCKING in [Zhang, Yu; Fu, Xi; Yan, Yangting; Liu, Jinbing] Shaoyang Univ, Dept Food & Chem Engn, Shao Shui Xi Rd, Shaoyang 422100, Peoples R China in 2020, Cited 45. Formula: C8H7NO3. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6
In this work, we have synthesized a series of 2-thiazolylhydrazone derivatives (1-27) and investigated their biological activities as tyrosinase inhibitors and antioxidants. Some compounds showed potent tyrosinase inhibitory activities and 4-(2-(2-(1-(4-Aminophenyl)ethylidene)-hydrazinyl)thiazol-4-yl) phenol (26) showed more potent inhibitory effect than the standard tyrosinase inhibitor kojic acid (IC50: 9.8 mu M vs. 23.6 mu M). Compounds 2, 14, and 26 exhibited high antioxidant activities in 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2 ‘-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays. The structure-activity relationship (SAR) indicated that the substitutions of bromine, hydroxyl group, and amino groups cause great effect to the inhibition effect against tyrosinase. The mechanism and kinetic studies demonstrated that the inhibitory effect of compound 26 on the tyrosinase by acting as the reversible and uncompetitive inhibitor. Docking studies suggests that compound 26 interacts strongly with mushroom tyrosinase via hydrogen bonding.
Formula: C8H7NO3. Welcome to talk about 100-19-6, If you have any questions, you can contact Zhang, Y; Fu, X; Yan, YT; Liu, JB or send Email.
Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem