Synthetic Route of 4442-53-9, Chemical Research Letters, May 2021. The appropriate choice of redox mediator can avoid electrode passivation and overpotential, which strongly inhibit the efficient activation of substrates in electrolysis. 4442-53-9, Name is 2,3-Dihydrobenzo[b][1,4]dioxine-5-carboxylic acid,introducing its new discovery.
An efficient Rh/Cu-catalyzed method has been developed for the direct beta-arylation or alkenylation of ketones using (hetero)aryl or alkenyl carboxylic acids as coupling partners. This direct ketone beta-functionalization reaction proceeded via the merging of Cu-catalyzed ketone dehydrogenative desaturation and Rh-catalyzed carboxyl-directed C-H alkylation, exhibiting a broad substrate scope for both coupling partners. TEMPO proved to be essential for both dehydrogenation process and generation of the active Rh catalyst for C-H activation.
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