Recently I am researching about HYPERVALENT IODINE REAGENTS; FLUORINATION; SPIROLACTONIZATION; ALKENES; DEAROMATIZATION; OXIDATION; SYSTEMS; DESIGN; ROUTE; CF2, Saw an article supported by the NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USA [GM043214, GM121383, F32GM125187, F32GM128351]; NSFNational Science Foundation (NSF) [DGE1745303]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Levin, MD; Ovian, JM; Read, JA; Sigman, MS; Jacobsen, EN. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone. Recommanded Product: 1-(4-Nitrophenyl)ethanone
We report an iodoarene-catalyzed enantioselective synthesis of beta,beta-difluoroalkyl bromide building blocks. The transformation involves an oxidative rearrangement of alpha-bromostyrenes, utilizing HF-pyridine as the fluoride source and m-CPBA as the stoichiometric oxidant. A catalyst decomposition pathway was identified, which, in tandem with catalyst structure-activity relationship studies, facilitated the development of an improved catalyst providing higher enantioselectivity with lower catalyst loadings. The versatility of the difluoroalkyl bromide products was demonstrated via highly enantiospecific substitution reactions with suitably reactive nucleophiles. The origins of enantioselectivity were investigated using computed interaction energies of simplified catalyst and substrate structures, providing evidence for both CH-pi and pi-pi transition state interactions as critical features.
Recommanded Product: 1-(4-Nitrophenyl)ethanone. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Levin, MD; Ovian, JM; Read, JA; Sigman, MS; Jacobsen, EN or concate me.
Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem